Protective Effect of Mild-hypothermia on Brain of Newborn Rats with Bilirubin Encephalopathy
- VernacularTitle:亚低温对胆红素脑病仔鼠脑保护作用的实验研究
- Author:
Jinling LI
;
Lin LI
;
Cuiling LI
;
Hongxiang TAN
- Publication Type:Journal Article
- Keywords:
bilirubin encephalopathy, mild-hypothermia, neuron-specific enolase(NSE), S-100 protein, newborn rat
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(10):928-930
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of neuron-specific enolase(NSE),S-100 protein and TBC in the blood of newborn rats at early stage of bilirubin encephalopathy,and the protective effect of mild-hypothermia on the brain.Methods 42 Wistar rats(7-day postnatal) were divided randomly into the group C(control group,n=10),group M0(normal-temperature group,n=17) and group M1(mild-hypothermia group,n=15).The rats of the group C received physiological saline 0.5 ml,the rats in the groups of M0 and M1 were injected with bilirubin intraperitoneally(200 mg/kg) to establish the model of bilirubin encephalopathy.The changes of the content of NSE and S-100 protein in the blood of newborn rats,and the protective effect of mild-hypothermia on brain were observed.Results The animals with established bilirubin encephalopathy shown significant changes of neurobehaviour and pathological examination.Values of NSE and S-100 protein of the group M1 decreased after the treatment of mild-hypothermia,and there was a significant difference compared with group M0( P<0.01).Conclusion The mild-hypothermia has protective effect on brain of newborn rats with bilirubin intraperitoneally.
