Effect of Jintong Capsule on the Mice Models of Tourette Syndrome
- VernacularTitle:金童颗粒治疗抽动秽语综合征模型小鼠的药效学研究
- Author:
Ru-yi ZHANG
;
Lin LI
;
Li ZHANG
;
Houxi AI
;
Jin CHU
- Publication Type:Journal Article
- Keywords:
tourette syndrome, amphetamine, apomorphine, Jintong capsule
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(12):1065-1066
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe effect of Jintong capsule on model mice of tourette syndrome (TS).Methods TS models of mouse were established by intraperitoneal injection of amphetamine (AMP) or subcutaneous injection of apomorphine (APO). The animals were randomly divided into the normal control group, model group, Jintong capsule large dose group, Jintong capsule small dose group and haloperidol control group. The spontaneous movements and grasping action of model animals were observed and the contents of dopamine and its products of metabolism in striatum of animals were detected.Results The abnormal hyperactivity and the content of dopamine of Jintong capsule groups in striatum of AMP model mice were lower than that of the model group ( P< 0.05 ), and the grasping time of Jintong capsule groups in APO model mice shorten compare with the control group ( P<0.05).Conclusion Jintong capsule can ameliorate hyperactivity behaviors of these two animal models, and decrease the content of dopamine in striatum.
