Study of Bone Marrow Mesenchymal Stem Cells Differentiated into Neuron-like Cells Induced by Ganglioside in Vitro
- VernacularTitle:神经节苷脂体外诱导骨髓基质干细胞分化为神经元样细胞
- Author:
Jian YANG
;
Yi HONG
;
Hao DONG
;
Xiandi ZHANG
;
Shudong JIANG
- Publication Type:Journal Article
- Keywords:
bone marrow mesenchymal stem cells (BMSCs), ganglioside, induced differentiation, neuron-like cells
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(12):1054-1055
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possibility that bone marrow mesenchymal stem cells (BMSCs) differentiated into neuron-like cells induced by ganglioside in vitro.Methods BMSCs were separated, cultured and differentiate into neuron-like cells induced by ganglioside. Neuro-specific enolase (NSE) and neurofilament (NF) on the surface of differentiated and induced BMSCs were detected by immunocytochemistry.Results BMSCs were induced to differentiate into the cells with a typical neuronal morphology. The induced neuron-like cells expressed NSE and NF.Conclusion BMSCs can be differentiated into neuron-like cells by induction of ganglioside in vitro.
