Imageological Study of Primary Progressive Aphasia with One Case Report
- VernacularTitle:原发性进行性失语的影像学研究(附1例病例分析)
- Author:
Hui QU
;
Ruile FANG
;
Yumei ZHANG
;
Yongjun WANG
- Publication Type:Journal Article
- Keywords:
primary progressive aphasia, functional magnetic resonance imaging, pathogenic mechanism
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(8):774-776
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the imaging characteristics of one patient with primary progressive aphasia (PPA).MethodsThe patient was examined with MRI and functional MRI (fMRI) to perform the analyses of perfusion weighted imaging (PWI), magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI), and studied the changes of cerebral blood flow (CBF), metabolism, and association fibers of PPA.ResultsThere was frontal lobe and temporal lobe atrophy on general MRI, lower metabolism compared with contralateral on MRS; there were decreased association fibers between Broca domain and other domain, no association fibers between triangular area and Wernicke domain on DTI, mean fraction anisotropism (FA) and fibers of Broca and Wernicke domain decreased compared with healthy adult.ConclusionLeft temporal lobe and frontal lobe are the mainly diseased regions of PPA, and perfusion and metabolism are lower than the contral lobe, and the association fibers between Broca and Wernike domain are less than the control lobe.
