Semiquantitative and Qualitative Assessment of Functional Recovery after Spinal Cord Injury in Adult Rats
- VernacularTitle:半定量和定性方法评价截瘫大鼠后肢运动功能恢复的比较
- Author:
Ying ZHANG
;
Shu-rong JI
;
Xiao-hua FAN
;
Hongjun ZHOU
;
Genlin LIU
- Publication Type:Journal Article
- Keywords:
spinal cord injury, locomotor function, rehabilitation, assessment, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(11):957-959
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the characteristic of hindlimb movement recovery in adult rats after spinal cord injury and how to assess it.Methods 26 adult female rats were randomized in sham,completely midthoracic spinal cord transected(at T8 level) or body weight supported treadmill training(BWSTT) groups.Their motor function were assessed with Basso,Beattie,Bresnahan locomotor rating scale for open field(BBB scale) and average combined scores(ACOS).ResultsNone of the rats exhibited hindlimb movements after operation.30 d and 45 d after operation,BBB and ACOS score of rats in BWSTT group showed better than that in SCI group.There were significant differences in ACOS score among 15 d,30 d and 45 d after operation in both group.ConclusionPartial spontaneous hindlimb functional recovery can be found in chronic adult spinal cord injured rats and BWSTT would facilitate the recovery.Both semiquantitative and qualitative assessment were strongly correlated with locomotor recovery,but the semiquantitative assessment shows more sensitive.
