Repairing of Spinal Cord Injury with Schwann Cell Neurilemma Channel in Rats
- VernacularTitle:自体施万细胞神经膜管移植修复大鼠脊髓损伤的实验研究
- Author:
Feng NAN
;
Jing-nian LI
;
Jian-li DONG
;
Hongfei WANG
;
Haichao DONG
;
Yanming GAO
- Publication Type:Journal Article
- Keywords:
Schwann cell neurilemma channel(SCNC), spinal cord injury, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(11):954-956
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo apply the Schwann cell neurilemma channel(SCNC) in promoting the regeneration of injuried spinal cord.MethodsSpinal cords of rats after laminectomy at T8/9 were divided in 3 groups randomly: 10 rats were transplanted with SCNC(Group A);10 rats only made models(Group B);10 rats were as normal control group(Group C).All rats received behaviour survey and inclined plane test every week 8 weeks after operation.6 weeks after operation,they were measured with cortical somatosensory evoked potential(CSEP).And 8 weeks after operation,all specimens were studied histologically.ResultsCSEP could be recorded in group A and C,but not in group B.There were marked differenties between group A or C and group B in behavior survey,inclined plane test.Amount of nerve fibers regenerated through the injury gap in group A was significantly larger than that in group B.ConclusionSCNC could facilitate axonal regeneration and promote the repairing of injuried spinal cord.
