Efficacy and Safety of Pulse Magnetic Therapy System in Insomnia Disorder: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
- Author:
Jiwu LIAO
1
;
Sisi WANG
;
Borong ZHOU
;
Wei LIANG
;
Ping MA
;
Min LIN
;
Weisen LIN
;
Congrui LI
;
Xiaotao ZHANG
;
Hongyao LI
;
Yin CUI
;
Jiajia HU
;
Yuanyi QIN
;
Yanhua DENG
;
Aibing FU
;
Tianhua ZHU
;
Shanlian ZHANG
;
Yunhong QU
;
Lu XING
;
Wumei LI
;
Fei FENG
;
Xinping YAO
;
Guimei ZHANG
;
Jiyang PAN
Author Information
- Publication Type:Original Article
- From:Psychiatry Investigation 2023;20(6):559-566
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:This study’s objective is to assess the efficacy and safety of Pulsed Magnetic Therapy System (PMTS) in improving insomnia disorder.
Methods:Participants with insomnia disorder were randomly assigned to receive either PMTS or sham treatment for four weeks (n= 153; PMTS: 76, sham: 77). Primary outcomes are the Insomnia Severity Index (ISI) scores at week 0 (baseline), 1, 2, 3, 4 (treatment), and 5 (follow-up). Secondary outcomes are the Pittsburgh Sleep Quality Index at baseline and week 4, and weekly sleep diary-derived values for sleep latency, sleep efficiency, real sleep time, waking after sleep onset, and sleep duration.
Results:The ISI scores of the PMTS group and the sham group were 7.13±0.50, 11.07±0.51 at week 4, respectively. There was a significant group×time interaction for ISI (F3.214, 485.271=24.25, p<0.001, ηp 2=0.138). Only the PMTS group experienced continuous improvement throughout the study; in contrast, the sham group only experienced a modest improvement after the first week of therapy. At the end of the treatment and one week after it, the response of the PMTS group were 69.7% (95% confidence interval [CI]: 58.6%–79.0%), 75.0% (95% CI: 64.1%–83.4%), respectively, which were higher than the response of the sham group (p<0.001). For each of the secondary outcomes, similar group×time interactions were discovered. The effects of the treatment persisted for at least a week.
Conclusion:PMTS is safe and effective in improving insomnia disorders.
