Medial Arterial Calcification and the Risk of Amputation of Diabetic Foot Ulcer in Patients With Diabetic Kidney Disease
10.3346/jkms.2023.38.e160
- Author:
Joon Myeong SO
1
;
Ji Ho PARK
;
Jin Gyeong KIM
;
Il Rae PARK
;
Eun Yeong HA
;
Seung Min CHUNG
;
Jun Sung MOON
;
Chul Hyun PARK
;
Woo-Sung YUN
;
Tae-Gon KIM
;
Woong KIM
;
Ji Sung YOON
;
Kyu Chang WON
;
Hyoung Woo LEE
Author Information
1. College of Medicine, Yeungnam University, Daegu, Korea
- Publication Type:Brief Communication
- From:Journal of Korean Medical Science
2023;38(21):e160-
- CountryRepublic of Korea
- Language:English
-
Abstract:
We assessed the risk factors for major amputation of diabetic foot ulcers (DFUs) in patients with diabetic kidney disease (DKD) stages 3b–5. For DFU assessment, in addition to DFU location and presence of infection, ischemia, and neuropathy, vascular calcification was assessed using the medial arterial calcification (MAC) score. Of 210 patients, 26 (12.4%) underwent major amputations. Only the location and extension of DFU, represented by Texas grade differed between the minor and major amputation groups. However, after adjusting for covariates, ulcer location of mid- or hindfoot (vs. forefoot, odds ratio [OR] = 3.27), Texas grades 2 or 3 (vs. grade 0, OR = 5.78), and severe MAC (vs. no MAC, OR = 4.46) was an independent risk factor for major amputation (all P < 0.05). The current use of antiplatelets was a possible protective factor for major amputations (OR = 0.37, P = 0.055). In conclusion, DFU with severe MAC is associated with major amputation in patients with DKD.
