Injectable Poloxamer Hydrogel Formulations for Intratympanic Delivery of Dexamethasone
10.3346/jkms.2023.38.e135
- Author:
Thi Phuc LE
1
;
Yang YU
;
Ik Sung CHO
;
Eun Yeong SUH
;
Hyuk Chan KWON
;
Sun-Ae SHIN
;
Yong-Ho PARK
;
Kang Moo HUH
Author Information
1. Department of Polymer Science and Engineering, Chungnam National University, Daejeon, Korea
- Publication Type:Original Article
- From:Journal of Korean Medical Science
2023;38(17):e135-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:In this study, we prepared and evaluated an injectable poloxamer (P407) hydrogel formulation for intratympanic (IT) delivery of dexamethasone (DEX).
Methods:DEX-loaded P407 hydrogels were characterized in terms of thermogelation, drug loading capacities, particle size, and drug release. The in vivo toxicity and drug absorption of the DEX-loaded P407 formulation after IT injection were evaluated using an animal model by performing histopathological analysis and drug concentration measurements.
Results:The P407 hydrogel effectively solubilized hydrophobic DEX and demonstrated a sustained release compared to the hydrophilic DEX formulation. The in vivo study showed that the hydrogel formulation delivered considerable drug concentrations to the inner ear and displayed a favorable safety profile without apparent cytotoxicity or inflammation.
Conclusion:P407 hydrogel can be useful as an injectable inner ear delivery formulation for hydrophobic drugs due to their biocompatibility, drug-solubilizing capacity, thermogelation, and controlled release.
