Within-Host Evolution of SARS-CoV-2in a B-Cell Depleted Patient With Successful Treatment
10.3346/jkms.2023.38.e175
- Author:
Yae Jee BAEK
1
;
Gemma PARK
;
Jun Yong CHOI
;
Eun Jin KIM
;
Bryan Inho KIM
;
Jin GWACK
;
Ji Ye JUNG
Author Information
1. Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea
- Publication Type:Case Report
- From:Journal of Korean Medical Science
2023;38(22):e175-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Prolonged viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised host is a challenge as the treatment and infection control for chronic coronavirus disease 2019 infection is not well established and there is a potential risk of new variants emerging. A 48-year-old woman who underwent chemotherapy, including rituximab and steroid, had reactivation of SARS-CoV-2 68 days after the virus was first detected. She successfully recovered after receiving convalescent plasma and intravenous immunoglobulin. Genomic analysis demonstrated that viruses collected from the nasopharyngeal specimens at day 0 and day 68 had 18 different nucleotide mutations, implying within-host evolution after in-depth epidemiologic investigation.
