Evaluation of Vancomycin TDM Strategies: Prediction and Prevention of Kidney Injuries Based on Vancomycin TDM Results
10.3346/jkms.2023.38.e101
- Author:
Byungwook KIM
1
;
Sejung HWANG
;
Eunjeong HEO
;
Hyung-sook KIM
;
Jongtak JUNG
;
Eu Suk KIM
;
Hong Bin KIM
;
Kyunghoon LEE
;
Jeong Su PARK
;
Junghan SONG
;
Joon Hee LEE
;
Jae-Yong CHUNG
;
Kyoung-Ho SONG
;
Seonghae YOON
Author Information
1. Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul National University College of Medicine Seoul, Korea
- Publication Type:Brief Communication
- From:Journal of Korean Medical Science
2023;38(14):e101-
- CountryRepublic of Korea
- Language:English
-
Abstract:
The current guidelines for therapeutic drug monitoring (TDM) of vancomycin suggest a target 24-hour area under the curve (AUC 0-24 ) of 400 to 600 mg*h/L for serious methicillinresistant Staphylococcus aureus infections. In this study, the predictabilities of acute kidney injury (AKI) of various TDM target parameters, target levels, and sampling methods were evaluated in patients who underwent TDM from January 2020 to December 2020. The AUC 0-24 and trough values were calculated by both one- and two-point sampling methods, and were evaluated for the predictability of AKI. Among the AUC 0-24 cutoff comparisons, the threshold value of 500 mg*h/L in the two sampling methods was statistically significant (P = 0.042) when evaluated for the predictability of AKI. Analysis by an receiver operating characteristic curve estimated an AUC 0-24 cutoff value of 563.45 mg*h/L as a predictor of AKI, and was proposed as the upper limit of TDM target.
