A case of two consecutive deliveries in a woman with acromegaly.
- Author:
Hoon CHOI
1
;
Yeon LEE
;
Il Hyung CHUNG
;
Jang Hyun KOH
;
Mi Jin KIM
;
Young Goo SHIN
;
Choon Hee CHUNG
Author Information
1. Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. cchung@wonju.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Acromegaly;
Pregnancy;
Growth Hormone
- MeSH:
Acromegaly*;
Bromocriptine;
Female;
Glucose Intolerance;
Growth Hormone;
Growth Hormone-Secreting Pituitary Adenoma;
Humans;
Infant;
Infertility;
Insulin;
Insulin-Like Growth Factor I;
Magnetic Resonance Imaging;
Neoplasm, Residual;
Pituitary Diseases;
Pituitary Neoplasms;
Pregnancy
- From:Korean Journal of Medicine
2004;67(6):662-666
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acromegaly is a rare pituitary disorder and usually results from GH hypersecretion by a somatotroph adenoma. Disturbed pituitary function might lead to infertility or early pregnancy termination. Pregnancy in acromegaly is very rare. GH is a potent insulin antagonist, and pregnant patients with GH hypersecretion are prone to added glucose intolerance and diabetes. Pregnancy itself may impact the course of a pituitary tumor. In our case, pregnancy was uneventful and normal full-term infant was delivered at 1993 by vaginal delivery after transsphenoidal surgery and bromocriptine therapy. After delivery, GH and IGF-I level wasn't normalized. Postoperative pituitary MRI scan showed residual tumor. Therefore she received subsequent postoperative pituitary radiation (total dose : 5000 cGy). Next year, despite elevated GH and IGF-I, she delivered normal full-term infant. We report a case of two consecutive deliveries in a woman with acromegaly despite elevated GH and IGF-I levels after transsphenoidal surgery and radiation therapy.
