A Case of Cowden Syndrome Presenting with Diverse Cutaneous Manifestations
- Author:
Jongeun LEE
1
;
Dong Min SHIN
;
Se Jin OH
;
Ji-Hye PARK
;
Dongyoun LEE
Author Information
- Publication Type:Case Report
- From:Annals of Dermatology 2023;35(2):146-150
- CountryRepublic of Korea
- Language:English
- Abstract: Cowden syndrome is caused by mutations in the phosphatase and tensin homolog (PTEN) gene and is part of the PTEN hamartoma tumor syndrome. Skin lesions including trichilemmomas, acral keratosis, mucocunateous neuromas and oral paillomas are the most prevalent feature found in patients with Cowden syndrome. It also possesses an increased risk of developing malignancies including breast, thyroid, endometrial, and colorectal cancers.Due to the increased risk of cancer, early diagnosis and regular surveillance are important for Cowden syndrome patients. Herein, we report a case of Cowden syndrome with diverse cutaneous manifestations and thyroid cancer.
