Regulation of Pyroptosis in Gastric Cancer by Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20231492
- VernacularTitle:细胞焦亡在胃癌中的作用及中医药调控研究进展
- Author:
Bo CHEN
1
;
Xitong SUN
1
;
Wei WANG
2
;
Xinqian DONG
2
;
Haoran ZHOU
1
;
Zhen SUN
2
Author Information
1. Shandong University of Traditional Chinese Medicine（TCM）， Jinan 250014， China
2. Affiliated Hospital of Shandong University of TCM， Jinan 250014， China
- Publication Type:Journal Article
- Keywords:
pyroptosis;
gastric cancer;
virulence factor;
gasdermin E （GSDME）;
gasdermin D （GSDMD）;
NOD-like receptor protein 3 （NLRP3）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(15):212-220
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis， a new type of inflammatory programmed cell death， is different from apoptosis， necrosis， cytosis， ferroptosis， and autophagy. Pyroptosis is dependent on the activation of cysteine aspartate-specific protease （Caspase）， which cleaves key mediator proteins to form pores in the cell membrane and induces the maturation and release of the proinflammatory cytokines interleukin-1β and interleukin-18 into the extracellular environment， resulting in a cascade of inflammatory reactions. Gastric cancer as a malignant tumor of the digestive tract is refractory and has poor prognosis， and the chemoradiotherapy of this disease may lead to a variety of complications. At present， the pathogenesis of gastric cancer remains unclear. Studies have proved that pyroptosis is associated with the occurrence and development of gastric cancer， which has attracted wide attention. Pyroptosis is a double-edged sword for gastric cancer. On the one hand， it can release the contents of proinflammatory cells to amplify or maintain inflammation and induce the "inflammation-cancer" transformation of cells. On the other hand， pyroptosis can enhance the sensitivity of drugs for chemotherapy to improve the therapeutic effect and survival. In recent years， the anti-tumor mechanism of traditional Chinese medicine （TCM） has become a research hotspot as TCM has demonstrated significant effects in clinical application. Therefore， the regulation of pyroptosis by TCM may be a new direction for the treatment of gastric cancer in the future. Based on the available studies， this paper introduces the roles of pyroptosis-associated key proteins in the occurrence and development of gastric cancer. Furthermore， this paper summarizes the effects of TCM prescriptions and active ingredients on alleviating gastric mucosal damage， reducing the incidence of gastric cancer， and preventing tumor metastasis and recurrence by mediating pyroptosis pathways， aiming to provide new ideas for deciphering the mechanism of pyroptosis and exploring the TCM treatment of gastric cancer in the future.
