Mitochondrial oxidative stress in vascular endothelial cell and atherosclerosis
10.12206/j.issn.2097-2024.202205116
- VernacularTitle:血管内皮细胞线粒体氧化应激与动脉粥样硬化
- Author:
Daoxin WANG
1
;
Tianguang ZHANG
1
;
Chaoyu MIAO
1
Author Information
1. Department of Pharmacology, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Publication Type:Reviews
- Keywords:
mitochondrial oxidative stress;
endothelial cell;
atherosclerosis;
mechanisms of action
- From:
Journal of Pharmaceutical Practice
2023;41(6):329-334
- CountryChina
- Language:Chinese
-
Abstract:
The injury of vascular endothelial cell function is the beginning of the pathological process of atherosclerosis. Mitochondrial oxidative stress is closely related to vascular endothelial cell function, which causes the dysfunction of vascular endothelial cell by inducing mitophagy, reducing nitric oxide production, inflammation, cellular metabolic imbalance and apoptosis. Meanwhile, vascular endothelial cell could also maintain their homeostasis by regulating mitochondrial oxidative stress. The molecular signaling pathways of the vascular endothelial cell injury caused by mitochondrial oxidative stress in the pathological process of atherosclerosis were outlined in this review, which provided reference for further research on the molecular mechanism between mitochondrial oxidative stress and endothelial damage.
