Advances on effects and mechanisms of PM<sub>2.5 </sub>on occurrence and development of kidney diseases

VernacularTitle:PM_2.5对肾脏疾病发生发展的影响及其机制研究进展
Author: Mengqiu LU ¹ ; Zhijun HUANG ^{2
,

3} ; Bin YI ¹
Author Information

1. Department of Nephropathy, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
2. Department of Nephropathy, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China
3. Institute of Environment and Health, Central South University, Changsha, Hunan 410013, China.
Publication Type:Review
Keywords: fine particulate matter; kidney diseases; chronic kidney disease; end-stage renal disease; mechanism
From: Journal of Environmental and Occupational Medicine 2023;40(6):711-715
CountryChina
Language:Chinese
Abstract: Air pollution is a serious global public health problem. Air pollutants, especially fine particulate matter (PM_2.5), are associated with increased risks of various diseases. In recent years, studies have confirmed that PM_2.5 is closely related to chronic kidney disease, secondary kidney disease, and end-stage renal disease. This review summarized the effects of PM_2.5 and its components on kidney diseases, and the potential mechanism of kidney injury induced by PM_2.5 exposure from the aspects of inflammatory injury and oxidative stress, renal hemodynamic changes, and DNA damage and methylation, aiming to provide an insight for further mechanism research and the prevention and control of air pollution-induced kidney damage.