Prognostic Significance of Bcl-2 Expression in Ovarian Cancers.
- Author:
Gu KONG
1
;
Young Ha OH
;
Chan Pil PARK
;
Do Soo NAH
;
Yung Jin MOON
;
Kyung Tai KIM
;
Youn Yeoung HWANG
;
Jung Dal LEE
Author Information
1. Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Bcl-1 expression;
Ovarian cancer;
Recurrence and prognosis;
Immunohistochemitry
- MeSH:
Carcinogenesis;
Humans;
Immunohistochemistry;
Mucins;
Ovarian Neoplasms*;
Proto-Oncogenes;
Recurrence
- From:Korean Journal of Obstetrics and Gynecology
1997;40(10):2262-2268
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The protein encoded by the Bcl-2 proto-oncogene has been shown to prolong cell su-rvival by preventing cell death(Apoptosis) induced by many insults including cancer therap-eutic drugs. Recently many researches have elucidated the bcl-2 expression in several hu-man solid cancers. However, there is still a few avaiable data to determine the role of Bcl-2 expression in the ovarian carcinogenesis and its prognostic significance in ovarian can-cers. Hence, we examined the expression of Bcl-2 in 68 ovarian epithelial cancers using immunohistochemistry and determined whether Bcl-2 expression has prognostic significance in the ovarian epithelial cancers. We found Bcl-2 expression(>5% positive cell) in 31 patients(40%). Bcl-2 expression were exclusively negative in the mucinous type of the ovarian epithelial cancer. Bcl-2 exp- ression was not correlated with tumor stage(stage I & II vs III & IV, p=0.63). The patients with Bcl-2 positivity had lower recurrence rate than the patients with negativity at the se- cond look operation(p<0.01). Although there was a trend that the patients with Bcl-2 posi- tivity had better acturial survival than the patient with negativity, the stastical significance was not present(3 years acturial survival;+vs-;63%, 29%;p>0.05). These results sug- gest the Bcl-2 expression appears an early event in the ovarian carcinogenesis and has an inhibiting role in progression of ovarian tumor.
