Clinical features of ophthalmology in thyroid disease
- VernacularTitle:Бамбайн булчирхайн эмгэгийн үед үүсэх нүдний эмнэлзүйн онцлогийг тогтоосон судалгаа
- Author:
Oyungerel B
1
,
2
;
Erdenezul G
1
;
Misheel B
1
;
Uranchimeg D
3
;
Chimedlkhamsuren G
2
;
Nomin-Erdene M
4
;
Sarantuya J
2
Author Information
1. Department of Ophthalmic Surgery, The 3rd State Central Hospital
2. Department of Molecularbiology, School of Bio-Medicine, MNUMS
3. Department of Ophthalmology, School of Medicine, MNUMS
4. Department of Endocrinology, Center of Diabetes, The 3rd State Central Hospital
- Publication Type:Journal Article
- Keywords:
myasthenia gravis;
exophthalmos
- From:Innovation
2021;14(2-Ophthalmology):6-10
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:TED (thyroid eye disease) is an inflammatory disease of the orbit caused by
autoimmune diseases of the thyroid, which adversely affect the vision, appearance, and quality
of life. Exophthalmos and eyelid retraction are the main features of TED, which can lead to ocular
motility, diplopia, optic neuropathy, and permanent vision loss. The study aims to determine the
most common clinical signs of TED in Mongolians and define whether there is a correlation with
the levels of thyroid autoantibodies.
Methods:The study involved 102 patients with TED and 81 patients with Graves’ ophthalmopathy.
The clinical features of TED were identified and evaluated by activity score (CAS) and severity of
GO using the European Group of Graves’ Orbitopathy (EUGOGO).
Results:The mean age of TED patients was 42.6±11.2, which was younger than GD patients
(P=0.012). The current smoker was 24 patients (23.5%) with TED, which is relatively higher than GD
(P=0.0001). The most common ocular signs were eyelid retraction 80 (78.4%), proptosis 77 (75.5%),
diplopia 14 (13.7%) and 4% vision loss. There were no differences in proptosis between the right (18
mm, median) and left eye (17.8 mm, median) (P>0.05). The mean CAS score was 3.09±1.72 and
varied depending on gender and smoking. According to EUGOGO, 62.7% of the patients were
moderately severe. Only 7 % of the patients were in the sight-threatening stage, presenting optic
neuropathy and corneal breakdown. The mean TSI level in patients with TED was 37.95 ± 35.41 IU
/ ml, which was 2.7 times higher than the mean in patients with GD.
Conclusions:Eyelid retraction and exophthalmos are the most common clinical signs of TED.
Early diagnosis of these features can prevent complications of the disease. Determining serum TSI
levels will help in the treatment and monitoring of TED.
- Full text:InnoOpht-2021-14(2);6-10.pdf
