The comparison of retinal findings in end stage of CKD and in diabetic renal failure
- VernacularTitle:Бөөрний дутагдалтай өвчтөний нүдний угийг чихрийн шижинтэй болон чихрийн шижингүй бүлэгт харьцуулан үнэлсэн нь
- Author:
Altantsetseg A
1
;
Uranchimeg D
2
;
Batzorig B
2
Author Information
1. Orbita Eye Hospital
2. Mongolian National University of Medical Science
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
CKD;
renal failure;
posterior pole deposit
- From:Innovation
2021;14(1-Ophthalmology):14-17
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Retinal pathologic features are associated with inflammatory processes and
endothelial dysfunction, leading to circulatory abnormalities and reduced vascular reactivity.
Both retinopathy and nephropathy involve thickening of basement membrane and muscular
layers and increased leakage. These pathologic and hemodynamic abnormalities may occur
throughout the body and their effects on the retinal vasculature may be useful indicators of
cumulative microvascular damage from hypertension, inflammation, diabetes mellitus, and other
processes. Type 2 MPGN is an uncommon renal condition associated with electron dense deposits
in the lamina densa of the glomerular basement membrane with C3 found in the capillary loops
and mesangium. The deposits in the basement membrane can lead to a breakdown of the
blood-retinal barrier by interfering with the RPE layer, and type 2 MPGN has been described in
association with central serous retinopathy.
Purpose:To assess the retinal findings in end stage of Chronic kidney disease (CKD) and diabetic
renal failure
Methods:Data of diabetic renal failure (n=20, mean age 56.8±11.6), and end stage of CKD(n=83,
mean age 48.2± 11.6) were cross-sectional analyzed. Nonmydriatic fundus photographs of the
disc and macula in both eyes were obtained in all the subjects. The photographs were assessed
by ophthalmologist using the standard protocols. The following parameters were recorded:
BCVA, IOP, BP GFR, serum Creatinine, ophthalmic and fundus examination.
Results:Greater severity of retinopathy was associated with DM. The presence of vascular
abnormalities usually associated with Diabetes Mellitus ( DM) and was not associated with lower
estimated glomerular filtration rate. All of patients with DM (n=20, 100%) ,they have Diabetic
retinopathy. We found sight direct relationship between retinal posterior pole deposit with CKD
patients. Some of patients who have end stage of CKD, (n=18, 11%) they have retinal deposit on
their posterior pole.
Conclusion:Our findings show ,In participants with end stage of CKD, there was no significant
severe retinopathy. In summary, our study demonstrates that DM, is one of the leading cause of
irreversible vision loss. Every patients with DM need the ophthalmic follow up examination in every
six months.
- Full text:InnoOpht-2021-14(1);14-17.pdf
