Histopathological and immunohistochemical characteristic for lung cancer among Mongolian patients
- VernacularTitle:Уушгины хавдрын эмгэг бүтэцзүй ба иммуногистохимийн шинжилгээний онцлогийг судалсан дүн
- Author:
Tsend-Ayush B
1
;
Anarkhuu B
2
;
Nyamjargal B
2
;
Uranchimeg B
3
;
Bayarmaa E
1
;
Saymaa L
1
Author Information
1. Department of Pathology and Forensic Medicine, School of Bio-Medicine, MNUMS
2. Department of Pathology, National Cancer Center
3. Department of Pathology, Mongolia-Japan Teaching Hospital, MNUMS
- Publication Type:Journal Article
- Keywords:
lung cancer;
immunohistochemistry;
TTF-1;
napsin A;
p63profile
- From:Innovation
2021;15(1):4-11
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Lung cancer is the leading cause of cancer death in both men and women.
In the past decade, histopathological classification of lung cancer has become increasingly
important in selecting the appropriate treatment.
Methods:All cases of lung cancer diagnosed pathologically in the last 2.5-year period were
retrospectively identified at National Cancer Center and performed by descriptive case series
design.
Results:The average age of our participants was 62, of which 82.2% were men. A total of 214
cases of lung cancer were reported, including 142 (66.4%) squamous cell carcinoma (SCC),
34 (16%) adenocarcinoma (AC), 4 (1.7%) NSCLC, 29 (13.6%) small cell carcinoma (SmCC) and
5 (2.3%) cases of other/unspecified type. Based on only morphology, initially 32 (17.7%) cases
of NSCLC were diagnosed, whereas after immunohistochemistry (TTF-1 or NAPA positive/p63
negative, and vice versa) staining, this category reduced to 2.2%.
Conclusions:Among both males and females, SCC which is highly related to smoking was
the most common histologic type of lung cancer. Our results showed that an approach of using
only a two-antibody panel (p63 and TTF-1) might help in the reduction of diagnostic category of
NSCLC-NOS significantly.
- Full text:Innovation-2021-15(1);4-11.pdf
