Results of the bone healing performance of Osteo-calcium 5 on based preparation tested by internal fixation surgery patients
- VernacularTitle:Иноваци шингэсэн Остео кальци-5 бэлдмэлийн үйлдлийг дотуур бэхэлгээтэй хагалгаанд орсон үйлчлүүлэгчдэд судалсан үр дүн
- Author:
Vaanchigsuren S
1
;
Tuvshin
2
;
Seesregdorj S
2
Author Information
1. MNUMS, School of Medicine
2. MNUMS, International School of Mongolian Medicine
- Publication Type:Journal Article
- Keywords:
bone healing;
osteo calcium-5;
TGF-β1;
BMP-2
- From:Innovation
2020;14(2):16-20
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Even though there are lots of good treatment methods, medicines and
biomaterials in use for broken bones due to international scientific researches on the ossifying
process and its mechanism, which are being studied on high level and bringing new solutions,
there is still a lack of inexpensive but good quality medicines that have low side effects and
specifically targets on the enhancement of osteoblasts.
Despite of the level of fractures, therapeutic effects and multiple bone fractures, only certain
drugs and medicines such as solution of baragshun and rhodiola, kitchen grime, chili-san and
calcium are used for ossifying broken bones and fractures in Mongolia which indicates that there
are certain needs of new medicine and drugs.
Methods:Patients who had a intramedullary osteosynthesis surgery to deal with tibia bone
fractures were divided randomly into two groups; 1.5 gram Osteo calcium-5 is given to the
experimental group while the comparison group got Calcium nycomed D3 for 60 days.
X-ray pictures were taken at the 56th and the 84th day after the fractures were diagnosed and
analyzed by Warden method (et al 2009). TGF-β1, BMP-2 cytokines and alkaline phosphatase
were evaluated on the 3rd, the 14th and the 42nd day of the study.
Results:Compared to the comparison group, which used Calcium Nycomed D3, the experimental
group patient, who used osteocalcium-5, had a similar TGF-β1 level at the 3rd day (p=1.0), a
higher level at the 14th day (p=0.0001) and a lower level at the 42nd day (p=0.015).Analyzing
fracture ossifying process with the Warden et al method shows that the ossifying points of the
Osteo calcium-5 group were 1.73 on 53rd day and 2.79 on 84th day while the ossifying points of
the comparison group was 1.41 on 56th day and 2.35 on 84th day (p=0.034),( p=0.04).
Conclusions:According to the study, Osteo calcium-5 has proven to have better effects on
decreasing inflammation process and accelerating bone ossify, cartilage and bone formation
with the analysis of cytokine in serum and structure.
- Full text:Innovation-2020-14(2);16-20.pdf
