Study of β2-adrenergic Receptor Gene Arg16Gly Polymorphism in Elder Essential Hypertension
- VernacularTitle:老年原发性高血压患者β2肾上腺素受体基因Arg16Gly多态性研究
- Author:
Na WANG
;
Zhi WANG
- Publication Type:Journal Article
- Keywords:
essential hypertension, β2-adrenergic receptor, gene polymorphism
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(10):905-907
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the relationship between β2-adrenergic receptor (β2-AR) gene Arg16Gly polymorphism and essential hypertension (EH) in elder (≥60 years old).Methods150 old healthy controls and 115 old patients with EH (all of them without kin relation) were selected to test genotype of β2-AR by the technique of polymerase chain reaction-restriction fragment length polymorphism (PCR-PFLP).ResultsThe frequencies of three genotypes (Arg/Arg, Arg/Gly and Gly/Gly) were 22.81%, 53.51% and 23.68% in the EH group and 27.33%, 67.33% and 5.33% in the controls respectively. The frequencies of Arg and Gly allele were 49.56 % and 50.44% in the EH group, and 61.00% and 39.00% in the controls. There was a significant difference in distribution of alleles/genotypes between EH group and controls ( P<0.05).Conclusionβ2-AR Arg16Gly gene polymorphism is possibly associated with hypertension in this study population.
