Advance in Study of Neural Stem Cells Used for Treatment of Alzheimer's Disease (review)
- VernacularTitle:神经干细胞治疗阿尔茨海默病研究进展
- Author:
Qiang WU
;
Lu-si LI
- Publication Type:Journal Article
- Keywords:
neural stem cells, Alzheimer's disease, therapy, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(10):871-874
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is a common progressive degenerative disease of the central nervous system. It's also a main cause for dementia in presenium and senectitude. In the past few years, the discoveries in vitro expansion of neural stem cells (NSCs) indicate a new way for recovery and replacement of damaged neurons as well as reconstruction of the neural circuit, and offer a useful future therapy for AD. There are two main promising approaches in NSCs replacement therapy. They are endogenetic approach, inducing proliferation and differentiation of endogenetic NSCs, improving self-repair of central nervous system, and exogenous approach, ransplantation of exogenous tissue and promoting proliferation of endogenous NSCs. However, it may not become truth before the mechanism of NSCs' proliferation, migration, differentiation and it's integration with the host tissues to be elucidated.
