Accuracy of Choline PET/CT vs. Tc 99m Sestamibi SPECT/CT parathyroid imaging in comparison to histopathology in the diagnosis of parathyroid adenoma : A meta-analysis
- Author:
Bettina Karmel D. Tecson
1
;
Gari P. Danganan
1
;
Michele D. Ogbac
1
Author Information
1. Division of Nuclear Medicine, Philippine Heart Center
- Publication Type:Journal Article
- Keywords:
Choline PET/CT;
Tc 99m Sestamibi SPECT/CT Parathyroid Imaging;
Histopathology
- MeSH:
Parathyroid Neoplasms;
Hyperparathyroidism
- From:
The Philippine Journal of Nuclear Medicine
2021;16(1):36-43
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:In the advent of the recently accepted use of Choline in parathyroid PET/CT, we aimed to assess its accuracy in
diagnosing parathyroid adenomas in comparison to the Tc 99m Sestamibi SPECT/CT parathyroid imaging, with
histopathology as the reference standard.
Objective:To determine the diagnostic accuracy of Choline PET/CT in comparison to Tc 99m Sestamibi parathyroid
imaging in detecting parathyroid adenomas, with histopathology as the reference standard.
Methods:Cross-sectional studies from 2014 to 2019 were identified through MEDLINE, Pubmed, clinicaltrials.gov, and
Google scholar. Our literature search yielded 13 articles, of which only 3 met the set inclusion and exclusion
criteria.
Results:Three published cross-sectional studies were included with a total of population of 157 patients. Choline PET/CT
was found to have a pooled sensitivity of 0.99 (0.96 - 1.00), pooled specificity of 0.45 (0.17 - 0.77), positive
likelihood ratio of 1.79 (1.1 – 2.9), negative likelihood ratio of 0.03 (0.0 – 0.1), positive predictive value of 96.0%
(93.4 - 97.7%) and negative predictive value of 83.3% (39.0 - 97.6%), estimated with 95% CI. Tc 99m Sestamibi
SPECT/CT parathyroid imaging had a pooled sensitivity of 0.77 (0.70-0.84), pooled specificity of 0.45
(0.17 - 0.77), positive likelihood ratio of 1.43 (0.8–2.4), negative likelihood ratio of 0.49 (0.2–1.4), positive predictive value of 96.0% (93.4-97.7%) and negative predictive value of 83.3% (39.0-97.6%), estimated with 95% CI
Conclusion:Choline PET/CT showed superior sensitivity, negative predictive value and negative likelihood ratio over Tc 99m
Sestamibi SPECT/CT parathyroid imaging. The measured specificities, positive predictive values and positive
likelihood ratios of both modalities were found to be similar.
- Full text:Accuracy of Choline.pdf
