Correlation of fat mass with bone mineral density and FRAX-based fracture risk among postmenopausal Filipino women
- Author:
Davidson V. Pastran
1
;
Jerry M. Obaldo
1
Author Information
1. Division of Nuclear Medicine, Philippine General Hospital
- Publication Type:Journal Article
- MeSH:
Postmenopause;
Bone Density;
Fractures, Bone
- From:
The Philippine Journal of Nuclear Medicine
2021;16(1):18-24
- CountryPhilippines
- Language:English
-
Abstract:
Background:Post-menopausal women experiences changes in estrogen levels affecting body metabolism, which may lead to
weight gain and obesity. Moreover, one of the most prevalent diseases among this group is osteoporosis.
However, the relationship between fat mass and its protective property remains unclear. This study assesses the
correlation of fat mass with bone mineral density (BM) and 10-year FRAX based fracture probability among
Filipino women.
Methods:A cross-sectional review of records of post-menopausal Filipino women who underwent whole body bone
mineral densitometry scans via dual-energy X-ray absorptiometry (DXA) between January 1, 2015, and
December 31, 2018 in the Radioisotope Laboratory of the Philippine General Hospital was done. Pearson
correlation and simple linear regression analyses were done to determine the correlation between the two
outcomes – BMD and 10-year FRAX based fracture probability.
Results:A total of 258 postmenopausal women were included in the analysis. There was a weak positive correlation of
fat mass with BMD of L1-L4 vertebrae (R-score of 0.318), BMD of femoral neck (R-score of 0.3937) and hips
(R - score of 0.3031). The 10-year FRAX based fracture probability for both hip and osteoporotic had very weak
and weak negative correlation, respectively (R-score of - 0.06752 and - 0.29017).
Conclusion:Despite having varying available, data on the protective effects of fat mass on fracture protection, this study
showed that fat mass has a poor correlation with BMD and reduction in FRAX probability.
- Full text:Correlation of Fat Mass.pdf
