Research progress of the mechanism of traditional Chinese medicine in the prevention and treatment of athero-sclerosis based on miRNA regulation of vascular endothelial cell injury
- VernacularTitle:中药通过miRNA调控血管内皮细胞损伤防治动脉粥样硬化的作用机制研究进展
- Author:
Dandan LIU
1
;
Hewei QIN
1
,
2
;
Yang GAO
1
;
Mengyan SUN
1
;
Mengnan WANG
1
;
Yuqing NIU
1
;
Xuemei SONG
1
Author Information
1. School of Rehabilitation，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Dept. of Rehabilitation，the Second Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
microRNA;
endothelial cell injury;
atheroscle-
- From:
China Pharmacy
2023;34(12):1524-1528
- CountryChina
- Language:Chinese
-
Abstract:
The injury of vascular endothelial cells is not only the initial condition to promote the occurrence of early atherosclerosis （AS） plaques， but also an important link in the pathogenesis of AS. The microRNA （miRNA）， as an important medium of intercellular communication and gene regulatory factor， can affect vascular endothelial function and participate in the development of AS. The molecular mechanism of miRNA’s multi-target intervention in vascular endothelial cell injury has become a hot topic in the research of cardiovascular diseases. Monomers of traditional Chinese medicines such as ginsenoside Rb2 and paeonol， as well as traditional Chinese medicine for resolving phlegm and removing blood stasis could regulate miRNA to improve endothelial cell inflammation； astragaloside Ⅳ， dihydromyricetin and notoginsenoside could target miRNA and inhibit vascular endothelial oxidative stress； Danhong injection， Jianpi qutan and huayu prescription and paeonol could affect endothelial autophagy through miRNA； resveratrol， Bushen huoxue formula and Bushen tongmai formula could inhibit vascular endothelial aging by miRNA； dendrobine played an active role in regulating miRNA and improving endoplasmic reticulum stress. In the future， more in- depth research is needed on the effectiveness， mechanism of action， diagnosis and treatment plans， and safety of targeted regulation of miRNA for AS therapy by traditional Chinese medicine.
