Differential analysis of coumarins in Angelica dahurica from different origins
- VernacularTitle:不同基原白芷中香豆素类成分的差异分析
- Author:
Yingyu LIN
1
;
Yingying YANG
1
;
Enwei TIAN
1
,
2
Author Information
1. School of Traditional Chinese Medicine，Southern Medical University，Guangzhou 510515，China
2. Guangdong Province Key Laboratory of TCM，Guangzhou 510515，China
- Publication Type:Journal Article
- Keywords:
Angelica dahurica;
Non-targeted metabolomics technique;
multivariate statistical analysis;
coumarin;
origin
- From:
China Pharmacy
2023;34(12):1422-1425
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To screen the differential components of coumarins in Angelica dahurica from two origins （A. dahurica cv.‘ Hangbaizhi’； A. dahurica cv.‘ Qibaizhi’）. METHODS Non-targeted metabolomics technique of UPLC-Q-Exactive- MS/MS was used to analyze the coumarins in 6 batches of A. dahurica cv. ‘Hangbaizhi’ and 12 batches of A. dahurica cv. ‘Qibaizhi’. The differential components were screened by principal component analysis， partial least squares discriminant analysis and orthogonal partial least squares discriminant analysis. Cluster analysis was performed on differential components. RESULTS A total of 41 coumarins were identified in 18 batches of samples， in which 23 coumarins were differential components. Therein， 6 differential components were higher in content in A. dahurica cv.‘ Hangbaizhi’， while 17 differential components were higher in content in A. dahurica cv.‘ Qibaizhi’. The content of marmesin galactoside in A. dahurica cv.‘ Hangbaizhi’ was significantly higher than that in A. dahurica cv.‘ Qibaizhi’. Based on 23 differential components， A. dahurica cv.‘ Hangbaizhi’ and A. dahurica cv. ‘Qibaizhi’ could be grouped into one category， respectively. CONCLUSIONS The screened differential components of coumarins can be used to distinguish A. dahurica cv. ‘Hangbaizhi’ from A. dahurica cv. ‘Qibaizhi’， especially marmesin galactoside contributed the most， which can be used to identify A. dahurica cv.‘ Hangbaizhi’ and A. dahurica cv.‘ Qibaizhi’.
