Study on treatment outcome and risk factors of multidrug-resistant pulmonary tuberculosis patients in Shanghai
10.19428/j.cnki.sjpm.2023.22404
- VernacularTitle:上海市耐多药肺结核患者治疗结局相关因素研究
- Author:
Chenxi NING
1
;
Shiqi ZHANG
2
;
Zheyuan WU
1
;
Jing CHEN
1
;
Zurong ZHANG
1
;
Xin SHEN
1
;
Zheng'an YUAN
1
Author Information
1. Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
2. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Journal Article
- Keywords:
multidrug-resistant pulmonary tuberculosis;
treatment outcome;
influencing factor
- From:
Shanghai Journal of Preventive Medicine
2023;35(3):219-223
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo describe the characteristics of treatment outcomes of multidrug-resistant tuberculosis （MDR-TB） patients enrolled in second-line treatment in Shanghai from 2017 to 2018， and to analyze the influencing factors of treatment outcomes. MethodsTotally 182 MDR-TB patients were analyzed by using data collected from the China tuberculosis management information system， the hospital's electronic medical record information system， whole genome sequencing results and a questionnaire survey， and logistic regression analysis was used to analyze the factors affecting the success of treatment. ResultsIn 182 MDR-TB patients， the success rate of treatment was 65.4%， the loss to follow-up rate was 8.2%， the mortality rate was 4.9%， the unassessable rate was 13.7%， and the drug withdrawal rate was 7.7%. The factors affecting the success of treatment in MDR-TB patients included age （35‒ years old， OR=5.28， 95%CI： 1.58‒17.59， P=0.007； 55‒ years old， OR=16.30， 95%CI： 4.36‒60.92， P<0.001） and compliance to medication （OR=0.55， 95%CI： 0.42‒0.72， P<0.001）. ConclusionThe treatment success rate of MDR-TB patients in Shanghai from 2017 to 2018 is significantly higher than the average level in China. Older patients and patients with less compliant are at higher risk of adverse treatment outcomes.
