Progress in research on microenvironmental immune regulation related to tumor-derived exosomes
10.13200/j.cnki.cjb.003862
- VernacularTitle:肿瘤源性外泌体对微环境免疫调节的研究进展
- Author:
LIU Cuihua
- Publication Type:Journal Article
- From:
Chinese Journal of Biologicals
2023;36(4):501-
- CountryChina
- Language:Chinese
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Abstract:
Exosomes,a branch of extracellular vesicles,are nano-sized vesicle-like bodies with bilayer lipid membrane structure,which are secreted actively by multiple vesicles formed by intracellular lysosomal particles fusing with cell membrane. Exosomes carry a variety of signal molecules such as proteins,nucleic acids and lipids,which mediate the transmission of information between cells and regulate the surrounding environment. Tumor cells secrete more exosomes than normal cells,and tumor-derived exosomes(TEXs)play an important role in the formation and maintenance of immunosuppressive microenvironment conducive to the survival of tumor cells,which can induce immune surveillance and regulate immune function in vivo and in vitro. This paper reviews the research progress of TEXs on immunosuppression induced by the regulation of various immune cell functions and the immunomodulation of microenvironment.
