Research progress of interaction between peste des petits ruminants virus and host cells
10.13200/j.cnki.cjb.003866
- VernacularTitle:小反刍兽疫病毒与宿主细胞相互作用的研究进展
- Author:
JIN Li
- Publication Type:Journal Article
- Keywords:
Peste des petits ruminants virus(PPRV);
Innate immunity;
Immune evasion;
Apoptosis;
Autophagy;
Inflammasome
- From:
Chinese Journal of Biologicals
2023;36(4):489-
- CountryChina
- Language:Chinese
-
Abstract:
Peste des petits ruminants(PPR)is a highly contagious disease with high mortality which is caused by peste des petits ruminants virus(PPRV)infection and leads to enormous economic losses for sheep husbandry both at home and abroad. The knowledge of interactions between PPRV and host cells is the basis of understanding of the pathogenesis and the prerequisite of disease prevention and control. This paper reviews the studies on the activation of host innate immune response by PPRV infection,the immune evasion of PPRV mediated by viral protein products,and the induction of apoptosis,autophagy and inflammasome resistance to virus,which provides a reference for further discussion on the immune evasion of PPRV and the key nodes involved in the interaction between PPRV and the host,thus providing theoretical guidance for effective prevention and control of PPR transmission.
