Factor analysis on serum biomarkers in patients with stage Ⅰ silicosis
- Author:
ZOU Ji min YUAN Bao jun WANG Dong mei LI Chao GAO Li chang TONG Yan yan CUI Jing jing
- Publication Type:Journal Article
- Keywords:
Occupational silicosis Serum Factor analysis Chemokines Oxidation Antioxidant Biomarkers
- From:
China Occupational Medicine
2022;49(06):687-691
- CountryChina
- Language:Chinese
-
Abstract:
Objective ，
To investigate the role of serum chemokines and oxidative and antioxidant biomarkers in occupational
（ silicosis） Methods
silicosis hereinafter referred to as . A total of 58 patients with stage Ⅰ silicosis were selected as the
- （ ），
research subjects using convenient sampling method. The serum levels of nuclear factor erythroid 2 related factor 2 Nrf2
-（ - ） - （ - - ） -
heme oxygenase 1 HO 1 and 8 isoprstaglandin F2α 8 iso PGF2α were determined by enzyme linked immunesorbent assay.
（ ） （ - ）
The serum levels of lipid peroxide LPO and total antioxidant capacity TAOC were determined by chemistry colorimetric method.
- - （ - ），
Luminex flow fluorescence technology was used to detect the serum levels of interferon γ inducible protein10 IP10 macrophage
（ ）- ， - - （ ）
inflammatory protein MIP 1α MIP1β and macrophagederived chemokine MDC . The above indicators were analyzed by factor
Results -
analysis. The information extraction rate of the original indicators of the nine biomarkers was 58.5%96.5%. Four common
， ， （ ） ，
factors were extracted including Nrf2 antioxidant signaling pathway helper T cell Th 1 dominant chemotaxis the total
， ， ， ， ，
oxidation/antioxidant balance and Th2 dominant chemotaxis whose variance contribution rates were 32.2% 19.1% 16.4%
， ， Conclusion -
and 11.8% respectively and the cumulative variance contribution rate was 79.5%. Both the oxidant antioxidant
，
disturbance and the dominance chemotaxis are involved in the occurrence and development of silicosis and the Nrf2 antioxidant
signaling pathway plays the most critical role.
