Changes of renin-angiotensin-aldosterone system in workers exposed to noise
- Author:
WU Qi feng LI Qi ping LI Cong LIANG Wei hui LI Bin LI Wan li DENG Xiao feng
- Publication Type:Journal Article
- Keywords:
Noise Occupational exposure Angiotensin Renin Aldosterone Tinnitus Seniority
- From:
China Occupational Medicine
2022;49(06):640-644
- CountryChina
- Language:Chinese
-
Abstract:
Objective - （ ）- （ ）
To observe the effects of renin angiotensin Ang aldosterone system RAAS in workers exposed to
Methods - -
occupational noise. Forty five workers with suspected occupational noise induced deafness were selected as noise
， ，
exposure group using convenient sampling method. According to their tinnitus symptom noise exposure intensity and work age
- ， ，
they were divided into no tinnitus and tinnitus subgroups <90 dB and ≥90 dB subgroups work years <10 years and ≥10 years
subgroups. Another 45 workers with no occupational noise exposure history were selected as control group. The levels of plasma
（ ）， ， ，
renin activity PRA AngⅠ AngⅡ and aldosterone of the two groups were detected and the aldosterone to renin activity
Results
ratio was calculated. The diastolic blood pressure of the noise exposure group was higher than that of the control group
［（ ）vs（ ） ，P ］ ，
80±7 76±8 mmHg <0.05 . However there was no significant difference in systolic blood pressure between the two
（P ） （ ：
groups >0.05 . The level of plasma AngⅡ in the noise exposure group was higher than that in the control group median
vs ，P ） （ P ）
100.98 65.43 μg/L <0.05 . There was no statistical significance in other indexes between the two groups all >0.05 . The
（ ：
plasma AngⅡ level in < 90 dB subgroup in the noise exposure group was higher than that of the control group median 123.16
vs ，P ）
65.43 μg/L <0.05 . There was no statistical significance in other indexes among the two subgroups of tinnitus symptom or
（ P ）
work age in the noise exposure group and the control group all >0.05 . There were no significant differences in the abnormal
， （ P ）
rates of PRA AngⅡ and aldosterone in plasma between the noise exposure group and the control group all >0.05 .
Conclusion
Occupational noise exposure may affect RAAS and lead to increased plasma AngⅡ levels in the workers.
-
Tinnitus and work age may not affect RAAS in occupational noise exposure workers.
