Association between urinary polycyclic aromatic hydrocarbons metabolites and high-normal blood pressure in coke oven workers
- Author:
MA Yi fei YAO Xi yuan WANG Hui min FU Meng meng WANG Yi dong NIE Ji sheng
- Publication Type:Journal Article
- Keywords:
Polycyclic aromatic hydrocarbons Metabolite Coke oven workers Blood pressure Influencing factors
- From:
China Occupational Medicine
2022;49(06):621-625
- CountryChina
- Language:Chinese
-
Abstract:
Objective （ ）
To investigate the association between urinary polycyclic aromatic hydrocarbons PAHs metabolites
- Methods
and high normal blood pressure in coke oven workers. A total of 433 coke oven workers were selected as the study
-
subjects using convenient sampling method. They were divided into normal blood pressure group and high normal blood pressure
group according to their blood pressure level. The levels of ten kinds of urinary hydroxylated PAHs metabolites were measured by
- Results -
high performance liquid chromatography mass spectrometry. Among the subjects,57.5% had high normal blood
- ， - ， -
pressure. The levels of 1 hydroxynathalene 2 hydroxyphenanthrene 1 hydroxyphenanthrene and the metabolite of total PAHs
- （ P ）
in the high normal blood pressure group were higher than those in the normal blood pressure group all <0.05 . The results of
- ， - ， - ，
the multivariate logistic regression analysis showed that urinary 1 hydroxynathalene 2 hydroxyfluorene 3 hydroxychrysene
- （ P ），
and metabolite of total PAHs were all risk factors for high normal blood pressure in coke oven workers all <0.05 after
， ， ， ， ，
adjusting for confounding factors such as gender length of service body mass index smoking index alcohol consumption tea
， ， ， Conclusion
consumption night shift exercise frequency and other PAHs metabolites. Exposure to PAHs in coke oven
plants may increase the risk of elevated blood pressure within the normal range among coke oven workers.
