RESULTS OF THE STUDyOF THE PHARMACOLOGICAL ACTION OF EXPERIMENTAL DRUGSOF PLANT ORIGIN ON THE PATHOLOGICAL MODEL OF GASTRIC ULCERS
- VernacularTitle: RESULTS OF THE STUDyOF THE PHARMACOLOGICAL ACTION OF EXPERIMENTAL DRUGSOF PLANT ORIGIN ON THE PATHOLOGICAL MODEL OF GASTRIC ULCERS
- Author:
Davaasambuu T
1
;
Chimegee TS
;
Sosorburam B
;
Narangerel B
;
Ganbold D
;
Lkhagva L
;
Khurelbaatar L
Author Information
- Publication Type:Journal Article
- Keywords: Stomach, gastric ulcers, acetic acid, sialic acid
- From: Mongolian Pharmacy and Pharmacology 2013;2(1):45-
- CountryMongolia
- Language:English
- Abstract: Background: To investigate the pharmacological actions ofthree groups of drugs containing: Plantago major L. extract, Calendula officinalis L. extract,or mixtures of both. The three investigational drugs were compared to Omeprazole, a standard drug produced in Bulgaria, which inhibits thereleaseof enzymesof the secretary cellsof the mucous membranesof the stomach.[1]Materials and Methods:The effects of the medicinalsubstances were investigated on “Wistar” breed of white rats. Pathological model of ulcers wasformed by injecting the rats with 10% acetic acid./ Okabe, Koth.S1978 /. [2] The experimental animals were given either of the three versions of the new herbal medicine and compared to the rats given Omeprazole. After treatment the ulcer index, MDA and sialic acids in the serum were determined. [3]Result: The results showed that in the third day of the investigation, the sialic acid levels in the blood of the test group, which was given the mixture of the two plants, was significantly reduced (p<0.05) compared to the control group.Conclusion:This indicates that medicinal substances given to the rats, whichcontained the mixture of Plantago major L. and Calendula officinalis L. has accelerated the regeneration of the stomach, decreased the stomach cell damage and overall has antioxidant protective effects.Key words: Stomach, gastric ulcers, acetic acid, sialic acidReferences:1. алтанцэцэг а, амбага м. амьтнû гаралтай зарим бэлдмэлийн ходооднû салст бүрхүүлийн гэмтлээс хамгаалах идэвхи. “монгол туургатнû уламжлалт анагаах ухаан” оу-ûн эрдэм шинжилгээний бага хурлûн илтгэлийн хураангуй уБ .1995, х 40-43.2. Okabe S. Koth J.L and others. “Amer.jour. dig,dis,1971, vol16. pp.277-2893. стальная и.д и др. методопределения мда с помошью тиобарбитуровой кислотû. совр. методû биохимии.м, 1977, с 66-68.
