Change of follicle stimulating hormone and estradiol levels in aging women and their relevance
- VernacularTitle:Эмэгтэйчүүдийн насжилтын үеийн фолликул идэвхижүүлэгч даавар болон эстрадиолын түвшинд гарах өөрчлөлт, хоорондын хамаарал
- Author:
Batnaran D
1
;
Munkhtsetseg J
;
Enebish D
;
Narantsetseg L
Author Information
1. School of Biomedicine, Health Sciences University of Mongolia
- Publication Type:Journal Article
- Keywords:
female aging;
FSH;
estradiol;
menopause;
pituitary-ovary axis;
hormone;
- From:Mongolian Medical Sciences
2010;153(3):16-19
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:In females reproductive system aging is very important. Females spend the last 1/3 period of their life in insufficiency of sex hormone of late menopause. Due to decrease of ovary function noticeable change is detected in nervous endocrine system. Although menstrual cycle hasn’t been lost amount of FSH increased. It shows decrease of reproductive function females. Therefore recently researchers define that amount of FSH increase is an important biomarker which detects in an early period of menopause. But amount of estradiol hormone is almost in normal level until the late post menopause. Goal: to study the dynamic feature of age related changes and dependence of serum FSH and estradiol level in female aging.Materials and Methods:In this study were involved 177 healthy Mongolian women aged above 35 years old. We drained 5 ml fasting vein blood at 8.00-10.00 am. Sera were separated and kept frozen until assayed by ELISA. Results:Аaverage mean of FSH was 19.84±22.6 IU/l, at the age of 35-45 1.62±3.29 IU/l, at the age of 46-55 16.39±15.39 IU/l, at the age of 56-65 31.38±33.69IU/l, at the age of 66-75 28.83±17.31 IU/l, over 75 34.52±13.94 IU/l and there was positive correlation between age and FSH levels (r=0.647, p<0.001).Average mean of estradiol of participants: at the age of 35-45 37.03±22.09 pg/ml, at the age of 46-55 21.1±16.65pg/ml, at the age of 56-65 13.7±20.07 pg/ml, at the age of 66-75 9.11±15.1pg/ml, over 75 age 1.8±1.53 pg/ml and there was inverse correlation between age and estradiol levels (r= -0.453, р<0.001).There was an inverse correlation between log E2 and FSH levels (r= -0.434, p<0.001). Multiple regression analysis shows that age (β= -0.350, p<0.001) and FSH (β=-0.222, p=0.016) had significant inverse correlation with serum estradiol level. Conclusion: For females over 35 average mean of FSH is 19.84±2.26 IU/l, average mean of estradiol hormone is 19.6±2.0pg/ml. between the mid age (35–45 years) and oldest (>75 years) groups, mean estradiol level declined by 20.6 times, whereas FSH increased by 21.3 times. It shows that this is an important marker of menopause. Multiple regression analysis shows that age (β= -0.350, p<0.001) and FSH (β= -0.222, p=0.016) had had significant inverse correlation with serum estradiol level.
