Results of the study of the pharmacological action of the liver hydrolyzate
- VernacularTitle:Элэгний гидролизатын фармакологийн үйлдлийг судалсан үр дүн
- Author:
Davaasambuu T
1
;
Oyunchimeg B
;
Chimegee TS
;
Sosorburam B
;
Narangerel B
;
Ganbold D
;
Lkhagva L
;
Khurelbaatar L
;
Bayarjargal M
;
Gan-Erdene T
Author Information
1. Drug Research Institute
- Publication Type:Journal Article
- Keywords:
liver hydrolysate;
acute hepatitis;
liver enzymes;
carbon tetrachloride;
- From:Mongolian Medical Sciences
2012;162(4):78-85
- CountryMongolia
- Language:Mongolian
-
Abstract:
BackgroundLiver protecting effect of liver hydrolysate is studied on CCl4 induced by acute toxic hepatitis on rats compared with “Raw Liver Glandular” which is similar product of “Swanson”, USA. Result was confirmed with histological study.Materials and MethodsCarbon tetrachloride-CCl4 is considered as a direct hepatotoxin which produces centri-lobular necrosis and steatosis. The mechanism of acute toxic hepatitis induced by CCl4 involves lipid peroxidation of membrane bound fatty acids which result in destructing the cell membrane and the intracellular organells of the hepatocyte.Result:As study result, after 7 days CCL4 exposure, experimental group’s serum ALAT (p<0.01), GGT (p<0.05) and ALP (p<0.05) levels decreased rapidly compared with control groups.ConclusionAlthough, liver hydrolysate is not medicine for treatment liver damage, it might be improved regeneration process in the damaged liver cells. As result, histomorphological study came to the following conclusion: in the seventh day of the model of acute toxic hepatitis of the liver in rats, cytoplasm vacuoles of hepatocytes were decreased sharply, hepatocytes became multilateral, “Kupffer cells” were increased, young hepatocytes were streamlined as columnar-cells, capillaries were became visible and was began regeneration. There were reported that bovine and pork protein hydrolysate contains essential amino acids with antioxidant effect which prevents liver cells from oxidative stress. Besides it, liver hydrolysate containing amino acids, vitamin B1, B6, folic acid and some minerals improves metabolism and regeneration process of damaged liver cells.
