The assessment of cognitive impairment in patients with Parkinson’s disease using by neuropsychological tests
- VernacularTitle:Паркинсоны өвчний үеийн танин мэдэхүйн өөрчлөлтийг мэдрэл-сэтгэлзүйн сорилуудаар харьцуулан судалсан дүн
- Author:
Khandsuren B
1
;
Bayasgalan TS
Author Information
1. Medical Sciences Institute of Mongolia
- Publication Type:Journal Article
- Keywords:
Parkinson’s disease;
cognitive impairment;
MoCA;
MMSE;
- From:Mongolian Medical Sciences
2012;161(3):25-29
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background: Cognitive impairment (CI) is common in Parkinson’s disease (PD) and 20%-80% of patients with PD will develop dementia over time. The Montreal cognitive assessment (MoCA) is a short cognitive screening tool for CI in PD patients. The mini-mental state examination (MMSE) often fails to detect early cognitive decline.Objective: The aim of this study is to compare MMSE to MoCA scores in Mongolian patients with Parkinson’s disease.Methods: Clinical history of 47 patients with diagnosis of PD in according to clinical criteria of the UKBBPD has been enrolled. The patients were assessed using Hoehn and Yahr stage (HY), Unified Parkinson’s Disease Rating Scale (UPDRS III parts), MMSE and MoCA. Patients normal and with CI were classified using cut-off MMSE and MoCA scores 25 or below.Results: Total 47 patients: 21 male (44.7%) and 26 female (55.3%) patients were included. The mean age was 64.2±2.6 years, the mean HY stage was 2.4±0.3 and the mean disease duration was 5.5±1.2 years. The mean MoCA score was 25.7±3.1 (SD 4.3; range 13-30) with the following distribution for categories: normal in 42.6% (20 cases) and CI in 57.4% (27 cases) of patients and the mean MMSE score was 27.2±0.8 (SD 2,8; range 18-30) with the following distribution for categories: normal in 72,3% (34 cases) and CI in 27,6% (13 cases) of patients with PD. Patients with cognitive impairment had advanced HY stage (p<0.05) and greater motor deficiency on UPDRS III (p<0.05) than patients without cognitive impairment. In contrast, there were no significant differences in age, disease duration and onset of disease. Cognitive impairments on the MoCA were seen in numerous cognitive domains, including visuospatialand executive abilities (40.4%), attention (57.4%), abstraction (53.1%), memory (93.6%) and language (68.0%), naming and orientation (8.5%) and on the MMSE were seen in some cognitive domains, including attention (36%), memory (57%) and language (23%) and orientation (19%) respectively.Conclusion:• 57.4% and 27,6% of the patients with PD have cognitive deficits based on their MoCA and MMSE score. This suggests that the MoCA will be more sensitive than the MMSE to detect cognitive impairment in PD patients.• Cognitive impairment was more common in PD patients with advanced HY stage and severe motor symptoms.• Attention, language and memory impairment, executive function and language were the most common patterns of CI in PD patients valued by the using of the MoCA and MMSE.
