The pharmacology study result of kidney inflammation treatment active preparation
- VernacularTitle:Бөөр эмчлэх үйлдэлтэй бэлдмэлүүдийн фармакологийн судалгааны үр дүнгээс
- Author:
Davaasambuu T
1
;
Chimgee TS
;
Khashchuluu B
;
Bayaraa S
;
Odchimeg B
;
Bayanmunkh A
;
Lkhagva L
;
Khurelbaatar L
Author Information
1. Drug research institute
- Publication Type:Journal Article
- Keywords:
kidney;
kanamycin sulfate;
creatinine;
urea test;
- From:Mongolian Medical Sciences
2014;169(3):55-58
- CountryMongolia
- Language:Mongolian
-
Abstract:
IntroductionNumber of kidney acute and chronic disease is increasing rapidly in the world and becoming the majorcause of death even population employment capacity is invalid. Statistical report of Mongolian Ministryof Health last 5 years statistic kidney disease is in the 3rd of non-contagious disease Synthetic andchemical medicines used for this sort of disease would have side effects in some cases. Plants, animalsand minerals biologically active substances, side effects need to produce new drugs, has attracted theattention of researches.GoalIdentifying pharmacology act of new granule medicine preparation.Material and Methods: The effects of the medicinal substances were investigated on “WISTAR” linesof white rat. Pathological model of nephritis was formed by injected the rats with kanamycin sulfate(Mondodoev.A.J, Lameza.S.B, Bartonov.E.A, 1988). The experimental animals were given any of thenew granular herbal medicine and compared to the rats given Nefromon. After treatment the creatinine,urea acid and MDA in the serum were determined. MDA is identified by an amount of concentration andmethod (Stalinaya. I.D. 1977).ResultCreatinine amount of disease model group of kidney illness created by kanamycin sulfate is comparedwith healthy group animals and 1.64 times, carbamide amount is 4.25 times, rest of the azote’s 2.73are increased and comparing the experiment group creatinine amount is 1.65 creatinine amount is 1.65decreased comparing with disease model group.ConclusionWhen compound ingredients preparation creates experiment animal kanamycin sulfate oxidantdominates, intensify the kidney cell active, decrease the carbamide and creatinine and decrease thekidney cell necrosis.
