Hypothesis of effects for ellipin on cancer cells Molecular mechanisms involved
- VernacularTitle:Элэгний хавдрын эсэд эллипин бэлдмэл нөлөөлөх тухай молекул механизмын таамаглал
- Author:
Bayanmunkh A
1
;
Khurelbaatar L
;
Lkhagva L
Author Information
1. Drug Research Institute
- Publication Type:JOurnal Article
- Keywords:
Ellipin;
cancer;
molecular mechanism;
- From:Mongolian Medical Sciences
2014;169(3):8-13
- CountryMongolia
- Language:Mongolian
-
Abstract:
The Ellipin, derived from bovine liver, is a newly developed agent containing several important fattyacids and may have anticancer effects on cancer cell in vitro culture. This Ellipin preparation containmany PUFAs and those are important molecules for membrane order and function; they can modifyinflammation-inducible cytokines production, eicosanoid production, plasma triacylglycerol synthesisand gene expression. Recent studies suggest that anti-proliferation effect on in vitro cancerous cell linese.g. J62, Raji, Hela, K582, and in vivo it minimized and decreased the growth of U14 cervical cancer inmice and suppressed the growth of its S37 sarcoma cells, increased the area of dead cancer cells, anddecreased the angiogenesis. Also it can be cancer chemopreventive and auxiliary agents for cancertherapy. The Ellipin could alter cancer growth influencing cell replication, cell cycle, and cell death.However, the effects of the Ellipin function on tumor growth in vivo have not been studied completlyand the mechanisms remain unclear. The question that remains to be answered is how, which pathwayEllipin can affect so many molecular ways inside cancer cell. We hypothesize that Ellipin’s mixture ofunsatured fatty acids effect inductor molecules in cancer gene which inhibits a repressor protein bindingto promotor and synthesis signaling molecules (caspase protein, TNF- ¹) in liver cancer cell. Also italter membrane stability and modifing cellular signalling.
