The neuroprotective effect of complex herbal medicine «Sedaphyte» on ethanol induced experimental alcoholic chronic intoxication
- VernacularTitle:Архины шалтгаант архаг хордлогын үед ургамлын гаралтай “Седафит” бэлдмэлийн мэдрэлийн тогтолцоог хамгаалах үйлдэл
- Author:
Dashnamjilov J B
1
;
Ambaga M
;
Nikolaev С М
Author Information
1. Institute of General and Experimental Biology, Siberian Branch of Russian Academy of Sciences Ulan-Ude, Russian Federation
- Publication Type:Journal Article
- Keywords:
alcoholic intoxication;
activity of catalase;
inactive - unconditional reflex;
malondialdehyde;
Sedaphyte;
- From:Mongolian Medical Sciences
2015;172(2):110-114
- CountryMongolia
- Language:Mongolian
-
Abstract:
BackgroundThe overindulging alcohol leads to the structural changes in neurons of the brain, and to damages ofthe brain cognitive processes.GoalTo determine the neuroprotective effect of complex herbal medicine «Sedaphyte» on ethanol inducedexperimental animal model.MethodsWe determined an abilities of avoid the inactive - unconditional reflex of rats on ethanol inducedexperimental model in dose 40% ethanol 9 ml/кg during 45 days per os. We were measured thequantity of malondialdehyde (MDA) and the activity of catalyze in brain tissue and analyzed thehistology of brain tissue. The water infusion of complex herbal medicine «Sedaphyte» used in dose1,0 ml/100g, also in comparison group was used Pyracetam in dose 200 mg/kgResultsThe complex herbal medicine «Sedaphyte» preserved the inactive - unconditional reflex of rats onchronically administrated ethanol in the form of keep in the dark chamber period was enhanced in67 - 70% after 24 hours and in 44, 3 - 66, 8% after 7 days in comparison with control group. Also“Sedaphute” was decreased the amount of dark hyperchromic cell in hippocampus of rats brain onethanol - induced alcoholic intoxication in 40%, the concentration of MDA in 52% and enhanced thecatalyse activity in 30% in comparison with control group.Conclusion. Our studies were shown that the complex herbal medicine “Sedaphyte” hasneuroprotective effect in the experimental alcoholic intoxication. The principal mechanism of thispharmacological neuroprotective action is connected with the inhibition on lipid peroxidation andstimulatation on the antioxidant system of complex herbal medicine “Sedaphyte”.
