Clinical Observation on Effect of Nicorandil in Angina Pectoris.
10.4070/kcj.1987.17.3.519
- Author:
Kyung Ho LEE
;
Won Tae CHUNG
;
Jang Geun PARK
;
Gyo Ik SOHN
;
Woung Woo SHIN
;
Yeong Kee SHIN
- Publication Type:Original Article
- MeSH:
Angina Pectoris*;
Blood Pressure;
Edema;
Electrocardiography;
Headache;
Heart Rate;
Humans;
Male;
Myocardial Ischemia;
Nicorandil*
- From:Korean Circulation Journal
1987;17(3):519-525
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We evaluated the clinical effects of Nicorandil in 27 patients (17 male and 10 female) with ischemic heart disease (17 patients of stable effort angina, 3 patients of unstable effort angina, 6 patients of spontaneous angina, 1 patient of variant angina) in terms of the effect on the anginal pain, electrocardiographic changes and side effects. The results obtained were as follows; 1. The pulse rate was not changed by the drug administration and blood pressure were decreased slightly by Nicorandil in a daily dose of 15 mg divided into 3 dose, but these decrease were not significant in statistical meaning. 2. Improvement in EKG changes was observed in 9 patients (69%) among the 13 patients who showed abnormal EKG initially. 3. Anti-anginal effect of nicorandil were excellent in 14 patients, good in 8 patients, fair in 3 patients and so the rate of global improvement was 82%. 4. Nicorandil had side effects in 7 patients, headache (4 patients), palpitation, ocular pain, edema, but these were transitory and tolerable except of one case who could not be continued because of severe headache.
