Epidemiology of neurohereditary diseases in the population of some provinces (aimags) existence in south and central part of Mongolia
- VernacularTitle:Монгол орны зүүн ба төвийн бүсийн зарим аймгийн хүн амын дунд мэдрэлийн удамшлын өвчний (МУӨ) бүтэц, тархалтын төвшин
- Author:
Baasanjav D
1
;
Erdenechimeg YA
;
Chimeglkham B
;
Sarantsetseg T
;
Oyungerel B
;
Bolormaa D
Author Information
1. Medical Research Institute
- Publication Type:Journal Article
- Keywords:
neurohereditary diseases;
myotonic dystrophia;
hereditary muscular diseases
- From:Mongolian Medical Sciences
2014;168(2):12-17
- CountryMongolia
- Language:Mongolian
-
Abstract:
BACKGROUND:Our previous study has shown that the prevalence and structure of the neurohereditary diseaseswere different by provinces and some form of these diseases as “indigenous” in some isolatedpopulation. There are some scientific results of our researches–genetics about consanguineous,which is more potential factor of community is some area of Mongolia. All these circumstance isgiving to carry out this study.MATERIALS AND METHODS:We used descriptive epidemiological method for revealing hereditary neurological diseases in thepopulation of 6 provinces (aimags) of Mongolia: Dornogobi (Easth-gobi), Sukhbaatar, Gobisumber,Central aimag, Bulgan, and Darkhan-Uul. Total population of these provinces is 363072. Thenumber of population in 6 provinces was fluctuated in the range from 15.000 (Govisumber) to 88.875(Darkhan-Uul). Prevalence was accounted for 100.000 populations.RESULTS:The prevalence of neurohereditary diseases makes up 17.08 cases per 100.000 populations amongthese 6 provinces. 79% of these are hereditary neuromuscular diseases i.e 49 patients from 29families. Myotonic dystrophia and genetic neuropathies Charcot-Marie-Tooth have comparativehigh prevalence over test forms of disease.The high rate neurohereditary diseases was established in the population of Bulgan (35.80•10-5),Sukhbaatar (31.17•10-5), and Dornogobi (21.33•10-5) provinces. Their prevalence’s prevailed in the7-10 times over rates Darkhan-Uul, 3-5 times over rates of Gobisumber aimags.No neuromuscular forms of neurohereditary diseases i.e spastic paraplegia (11.3%) andspinocerebeller ataxia (9.68%) accounts for 21% among all forms of neurohereditary diseases.The prevalence of neuromuscular diseases in the population of these six provinces is two times highthen the average rate of the population of Russia (1980 years). First reason is may be associatedwith high predisposition of based on consanguineous through reproductive way in some of theseprovinces of Mongolia.
