Detection of serological autoantibodies in patients with autoimmune diseases
- VernacularTitle:Эрхтэн өвөрмөц бус аутоиммун өвчний үед ийлдсийн ауто-эсрэгбие илрүүлсэн дүн
- Author:
Ariuntuya S
1
;
Saruultuvshin A
;
Enkhtuya D
;
Zulgerel D
;
Tsogtsaikhan S
;
Batbaatar G
;
Chimidtseren S
Author Information
1. Department of Microbiology and Immunology, School of Biomedicine
- Publication Type:Journal Article
- Keywords:
autoantibodies;
autoimmune disease;
glomerulonephritis;
systemic lupus erythematosus
- From:Mongolian Medical Sciences
2014;167(1):3-6
- CountryMongolia
- Language:Mongolian
-
Abstract:
INTRODUCTION: In the modern medical practice of Mongolia, autoimmune diseases have notbeen diagnosed in its early stage. The autoantibodies are useful in the patient’s early diagnosis,prognosing, and treatment of autoimmune diseases.GOAL: The aim of the study was to compare the prevalence and levels of autoantibodies in theserum of patients with autoimmune diseases.MATERIALS AND METHODS: This patient-based descriptive study involved 144 participants, withconfirmed diagnosis of autoimmune disease and glomerulonephritis (GN). Face to face interviewwas used to obtain necessary information followed by the physical examination and autoantibodies(anti-SS-A/Ro, anti-SS-B/La, anti-SCL-70, c/p-ANCA, anti-GBM, anti-Sm) measured by Enzyme-Linked Immunosorbent Assay (ELISA).RESULTS: The prevalence of anti-SS-A/Ro 38.6%, anti-Sm 25.7%, anti-SS-B/La 8.6%, c-ANCA7.14%, anti-SCL-70 1.4% were positive in autoimmune disease group (secondary GN), theprevalence of anti-SS-A/Ro 6.8%, anti-Sm 2.7%, anti-SS-B/La 2.7%, c-ANCA 1.4% were positivein primary GN group. A higher frequency of anti-SS-A/Ro 66.4%, anti-SS-B/La 22.8%, and anti-Sm38.4% was observed in the SLE group.CONCLUSIONS: Patients with autoimmune disease was significantly higherly younger and female.SLE associated with several auto antibodies (anti-SS-A/Ro, anti-SS-B/La, and anti-Sm) and eachof which are very useful in distinguishing patients with SLE from other autoimmune diseases.
