Hypertension: a risk factor for progression of chronic kidney disease
- VernacularTitle:Бөөрний архаг өвчин ба артерийн даралт хоорондын хамаарлыг судалсан нь
- Author:
Enhtamir E
1
;
Ariunaa T
;
Odhuu E
;
Munhzol M
Author Information
1. Health Sciences University of Mongolia
- Publication Type:Journal Article
- Keywords:
chronic kidney disease;
hypertension;
estimated glomerular filtration rate
- From:Mongolian Medical Sciences
2011;172(2):62-64
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background: The World Health Organization calls hypertension the number one risk factor for death in the world and it’s considered a significant risk for stroke, heart failure, and kidney failure. Hypertension is common in patients with chronic kidney disease (CKD), and high blood pressure (BP) has been associated with a decrease in kidney function. The purpose of this study was to determine the correlation between an estimated glomerular filtration rate (eGFR) and BP in the CKD patients. Methods: From a hospital-based population, 125 patients with CKD (mean age 40.30±10.82) were recruited. CKD was evaluated by the eGFR using the Cockcroft-Gault formula. Cardio-Ankle vascular index (CAVI) was determined as an index of arterial stiffness. BP was measured using a mercury sphygmomanometer after subjects had sat and rested for at least 15 minutes. Pulse pressure was calculated as the difference between systolic BP (SBP) and diastolic BP (DBP). Mean arterial pressure was calculated as DBP plus one-third (SBP-DBP).Results: When BP grows up, renal function (eGFR 113.72±57.85, 78.39±60.96, 60.56±55.71, 28.38±19.96) and arterial stiffness (CAVI 6.51±0.99, 6.90±1.05, 7.22±1.17, and 7.79±1.16) are decreased. Linear regression analysis indicated that eGFR was correlated significantly with SBP (β=-0.480, p< 0.0001) and hypertension time (β=-0.332), p<0.0001). SBP was the strongest risk factors for CKD with each SD increase in systolic blood pressure (1mmHg) associated with > 4% higher risk ( hazard ratio: 1.04; 95% Cl: 1.02-1.07).Conclusion: Increases SBP were significantly associated with CKD.
