Study the changes in the kidney structure with type 2 diabetic patients
- VernacularTitle:2-р хэв шинжийн чихрийн шижинтэй өвчтөний бөөрний бүтцийн өөрчлөлтийг судалсан нь
- Author:
Baigalmaa S
1
;
Galtsog L
;
Gelegjamts KH
;
Altaisaihan KH
;
Bolor-Erdene G
Author Information
1. Second General Hospital
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
glomerular basement membrane thickening;
mesangial expansion;
Kimmelstiel-Wilson nodule;
advanced glomerulosclerosis
- From:Mongolian Medical Sciences
2011;172(2):56-61
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background: In recent years, kidney complication of diabetes became the basic cause of the end stage of renal disease in many countries around the world and then primary kidney disease goes on the 2-3 places. Due to the fact that diabetes mellitus turns more and more into non-communicable worldwide epidemic, we faced the increase in kidney complication which is one of form of micro vascular complications. So, illness of every 1-2 in three patients to undergo a renal replacement therapy has been diagnosed as diabetic nephropathy and of course nephrologists could not leave this fact without their attention. Goal: To study a change in the kidney structure with type 2 diabetic patients. Materials and Methods: Within the scope of the research 35 autopsied passed way because of the type 2 diabetes in clinical hospitals. According to Tervaert classification of diabetic kidney pathology issued by American Society of Nephrology in 2006, changes in glomerular structure were divided into 4 classes. Ordinary staining methods as hemotoxilin eosin, Van Gizonestaning connective tissue, Periodic Acid- Schiff standing have been used.Results: 35 autopsied in total, including 23 male (65.7%) and 12 female (34.3%) were covered by this research. And glomerular basement membrane thickening discovered in 51.4%, mesangial matrix expansion in 34.2%, Kimmelstiel-Wilson nodule in 20% and advanced glomerulosclerosis in 8.5% of total cases, respectively.Conclusions:1. It is found that diabetic kidney can be classified by Tervaert classification using ordinary standing and PAS reaction on the light microscope.2. However, we faced an essential necessity to be armed with immunofluorescence and electron microscope for the purpose to improve diagnostic examination and establish classes more accurately.3. Today when the medical science develops as evidence-based medicine, a starting the kidney biopsy samples assaying become the vital issue in comparative studying the clinical stage of diabetic kidney pathology.
