Result of the an association between decreased estimated glomerular filtration rate and arterial stiffness in chronic kidney disease patients
- VernacularTitle:Бөөрний архаг өвчний үед зүрх-шагайн судасны индекс тодорхойлсон дүн
- Author:
Enkhtamit E
1
;
Ariunaa T
;
Odkhuu E
;
Munkhzol M
Author Information
1. Health Sciences University
- Publication Type:Journal Article
- Keywords:
chronic kidney disease;
cardio-gnkle vascular Index;
estimated glomerular filtration rate
- From:Mongolian Medical Sciences
2011;168(1):13-15
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background. Cardiovascular diseases (CVD) constitute major cause of death in patients with chronic kidney disease (CKD). It is well established that in decreased renal function is associated with an increased risk of arterial stiffness, so patients with end stage renal disease have a very high risk for cardiovascular events. There have been no reports of the assessment of arterial stiffness in patients at different stages of non diabetic CKD in Mongolia.Aim. The purpose of this study was to determine the correlation between an estimated glomerular filtration rate (eGFR) and cardio-ankle vascular index (CAVI) in the CKD patients. Material and Methods. From a hospital-based population, 125 patients with CKD (mean age 40.30±10.82) were recruited. CKD was evaluated by the eGFR using the Cockcroft-Gault formula. CAVI was determined as an index of arterial stiffness.Results. The mean CAVI was in CKD level l ( 6.00±0.81, p 0.0001), ll (6.90±0.77, p 0.0001), lll (7.42±0.65, p 0.0001), lV (7.63±1.22, p 0.0001) and V (8.02±1.27, p 0.0001). CAVI was negatively correlated significantly with eGFR (r=-0.596, p 0.0001) and age (r=0.543, p 0.0001). Linear regression analysis indicated that CAVI was correlated significantly with eGFR (β=-0.466, p 0.0001) and age (β=0.373, p 0.0001).Conclusion. Decreased eGFR is associated with an increased risk of arterial stiffness, and it could be a strong predictor of risk factor for CVD in CKD patients.
