Results of Physicochemical Properties and Pharmacological Study of the Preparation From Lonicera Altaica Pall
- Author:
Ariunaa Z
1
;
Khaidav1 TS
;
Uuganbayar B
;
Dagvatseren B
;
Galtsog L
Author Information
- Publication Type:Journal Article
- Keywords: Lonicera Altaica Pall; fatty acids; Carbon tetrachloride; Hepatic fibrosis
- From:Mongolian Medical Sciences 2009;148(2):42-45
- CountryMongolia
- Language:Mongolian
- Abstract: To explore the characteristics of this Lonicera Altaica, the author and her colleagues have been involved in the isolation and structure elucidation on this plant. During the course of this work, we were studied the plant was using by X-ray fl uorescence method at the institute of Physics and Technology of the Mongolian Academy of Sciences (MAS). Based on the results of multiemelent analyses, it was evident that potassium (23227 ppm) was found mainly in the plant and Se (0.34 ppm) preferably in the straw. In this study, the fatty acid composition plant was investigated. The fatty acid profi le analysis of the oil was also carried out by Gas Liquid Chromatography. The oil has three main fatty acids: palmitic, oleic and linoleic acids, linoleic acid being the most abundant. The plant content of the oil showed that 97.75% is unsaturated. It`s high content of linoleic acid is of particular interest especially in the fi ght against antioxidant and atherosclerosis. From the result of the study it was determined the preparation has no toxicity. This preparation has an anti infl ammatory and diuretic activity comparing with the control group. In this study, the protective effect preparation from Lonicera Altaica on liver infl ammation and fi brosis induced by carbon tetrachloride (CCl4) has been investigated in rats. Preparation from Lonicera Altaica signifi cantly suppressed CCI4-induced hepatic necrosis and infl ammation, as determined by the serum enzymatic activities of alanine and aspartate aminotransferase and serum alkaline phosphatase levels. In the histopathological study we carried out liver tissues from each rat were dissected; fi xed in 10 % neutralbuffered formalin. Microscopic examination was conducted on four m thick H. & E. stained sections from paraffi nembedded specimens. Treatment with preparation from Lonicera Altaica attenuated the necro-infl ammation and fi brogenesis in the CCI4-induced hepatic fi brosis, and thus it might be effective as a therapeutic anti-fi brotic agent.
