Progress on Pharmacological Effect of Terpinen-4-ol： A Review
10.13422/j.cnki.syfjx.20230639
- VernacularTitle:松油烯-4-醇的药理作用研究进展
- Author:
Qing DU
1
;
Yuxi ZHONG
1
;
Ming YANG
1
;
Lei CHEN
1
;
Huimin ZENG
1
;
Chongwen AI
1
;
Yongmei GUAN
1
Author Information
1. Key Laboratory of Modern Chinese Medicine Preparation， Ministry of Education，Jiangxi University of Chinese Medicine， Nanchang 330004， China
- Publication Type:Journal Article
- Keywords:
terpinen-4-ol;
terpene 4 alcohol;
monoterpene;
pharmacological activity;
action mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(14):265-271
- CountryChina
- Language:Chinese
-
Abstract:
Terpine-4-ol is abundant in nature. As a cyclic monoterpenoid compound， terpine-4-ol is distributed in a variety of natural plants. It is the main component and the key active substance in many traditional Chinese essential oils， such as Melaleuca alba essential oil and coral ginger essential oil. Terpine-4-ol has anti-microbial， anti-tumor， insecticidal， anti-inflammatory， and other effects. It can treat cancer， as well as oral and cardiovascular diseases with great safety. In terms of antibacterial activity， terpine-4-ol can destroy bacterial cell walls， improve membrane permeability， and regulate bacterial migration， reproduction， and other related genes to inhibit bacterial activity. In terms of antifungal activity， terpine-4-ol can bind with ergosterol in fungal cell walls to cause fungal death. In terms of insecticidal activity， terpine-4-ol can inhibit Na+ and K+-ATPase activity and cause the death of the insect. In terms of anticancer activity， terpine-4-ol can regulate the expression of apoptosis-related proteins in cancer cells， so as to control the apoptosis of cancer cells. In this paper， the pharmacological activity and action mechanism of terpine-4-ol were reviewed to provide a reference for further research and utilization of terpine-4-ol.
