Role of Nrf2/HO-1 Signaling Pathway in Myocardial Infarction and Traditional Chinese Medicine Intervention： A Review
10.13422/j.cnki.syfjx.20220890
- VernacularTitle:Nrf2/HO-1信号通路在心肌梗死中的作用及中医药干预研究进展
- Author:
Xiaobin ZHAO
1
;
Hugang JIANG
1
;
Xinqiang WANG
1
;
Jinyan HAN
1
;
Kai LIU
1
;
Yingdong LI
1
;
Xinke ZHAO
1
Author Information
1. Gansu University of Chinese Medicine，Lanzhou 730000， China
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
nuclear factor E2-related factor 2 （Nrf2）/heme oxygenase-1 （HO-1） signaling pathway;
traditional Chinese medicine;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(14):248-255
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction （MI） is a common cardiovascular disease in clinical practice and one of the main causes of cardiovascular mortality. Its pathogenesis is complex and associated with oxidative stress reactions. Nuclear factor E2-related factor 2 （Nrf2） is a key factor in regulating oxidative stress reactions. It can regulate the expression of heme oxygenase-1 （HO-1）， playing a role in maintaining the oxidative-reductive homeostasis in the body. During the course of MI， the biological activity and levels of Nrf2 and HO-1 decrease， leading to weakened tissue antioxidant and anti-inflammatory capabilities， endothelial damage in myocardial blood vessels， release of vascular cell adhesion factors， and impaired endothelial function. In recent years， many basic research studies have explored the role and mechanisms of traditional Chinese medicine （TCM） in treating MI by modulating the Nrf2/HO-1 signaling pathway. The results have indicated that the Nrf2/HO-1 signaling pathway is an important potential target for TCM in the treatment of MI. This article reviewed the mechanism of the Nrf2/HO-1 signaling pathway in MI and the research progress of TCM in targeting and regulating this pathway， aiming to provide a theoretical basis for the prevention and treatment of MI and further drug development.
