Natural Medicinal Components Mediating Pyroptosis by GSDMs in Anti-tumor Therapy： A Review
10.13422/j.cnki.syfjx.202202223
- VernacularTitle:通过GSDMs介导细胞焦亡的天然药物成分在抗肿瘤治疗中的研究进展
- Author:
Zhuo CHEN
1
;
Lu LU
1
;
Xinggang FANG
1
;
Xingrong GUO
2
;
Jie LUO
3
Author Information
1. Clinical College of Traditional Chinese Medicine， Hubei University of Chinese Medicine， Wuhan 430065， China
2. Hubei Key Laboratory of Embryonic Stem Cell Research， Shiyan 442099， China
3. Taihe Hospital， Affiliated Hospital of Hubei University of Medicine， Shiyan 442099， China
- Publication Type:Review
- Keywords:
pyroptosis;
gasdermins （GSDMs）;
gasdermin E （GSDME）;
gasdermin D （GSDMD）;
natural medicine;
anti-tumor therapy;
progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(14):226-238
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis， an atypical new cell death mode other than apoptosis and necrosis， has been discovered in recent years. Pyroptosis depends on the cleavage of gasdermins （GSDMs） by Caspases. The activated GSDMs act on the plasma membrane to form a perforation， which results in cell lysis and triggers inflammation and immune response. Pyroptosis can be induced by four distinct signaling pathways， including canonical and non-canonical inflammasome pathways， apoptosis-associated Caspases-mediated pathway， and granzyme pathway. In these signaling pathways， GSDMs are the executors of pyroptosis. Pyroptosis is associated with the death of tumor cells and the inflammatory damage of normal tissues. Recent studies have demonstrated that moderate pyroptosis can lead to tumor cell death to exert an anti-tumor effect， and meanwhile stimulate the tumor immune microenvironment， while it can promote tumor development. Despite the good performance， drug-based anti-tumor therapies such as tumor immunotherapy， chemotherapy， and targeted therapy have some shortcomings such as drug resistance， recurrence， and damage to normal tissues. The latest research shows that a variety of natural compounds have anti-tumor effects in the auxiliary treatment of tumors by mediating the pyroptosis pathways in a multi-target and multi-pathway manner， which provide new ideas for the study of anti-tumor therapy. We reviewed the molecular mechanism of pyroptosis and the regulatory role of pyroptosis in tumors and tumor immune microenvironment， and summarized the recent research progress in the natural medicinal components regulating pyroptosis in anti-tumor therapy， with a view to providing ideas for the research on the anti-tumor therapy based on pyroptosis.
